Synthesis and antiparasitic properties of new 4-N-benzylamino-4-hetarylbut- 1-enes

Abstract:

New derivatives of 4-N-benzylamino-4-hetarylbut-1-ene containing a pyridyl nucleus were synthesized from benzylamines and pyridine aldehydes. N-oxide derivatives were obtained from these homoallylamines. Study of the antiparasitic properties of obtained pyridine derivatives as well as of four related benzazepines previously described, was carried out using cytotoxicity assays against Trichomonas vaginalis and epimastigote form of Trypanosoma cruzi protozoa. Compounds showing activity against epimastigote T. cruzi were tested against the amastigote form; unspecific cytotoxicity against macrophages was also studied. © 2005 WILEY-VCH Verlag GmbH & Co. KGaA.

Año de publicación:

2005

Keywords:

• Antichagasic
• Trichomonacidal properties
• Homoallylamines
• Benzazepines
• N-oxides

Fuente:

scopus