Synthesis and antiprotozoal evaluation of new N⁴-(benzyl) spermidyl-linked bis(1,3,5-thiadiazinane-2-thiones)

Abstract:

The synthesis and in-vitro antiprotozoal evaluation of novel N 4-(benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thione) (bis-THTT) derivatives from N4-(benzyl)spermidine is disclosed. Several of the new bis-THTT have in-vitro activities against L. donovani and T. cruzi that are comparable or superior to those of currently employed protozoocidal agents. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

Año de publicación:

2008

Keywords:

• 1,3,5-thiadiazinane-2-thione
• Spermidine
• Protozoocidal activity

Fuente:

scopus