Synthesis and antiprotozoan properties of new 3,5-disubstituted- tetrahydro-2H-1,3,5-thiadiazine-2-thione derivatives

Abstract:

In a search for antiprotozoan compounds, 34 new 3,5-disubstituted- tetrahydro-2H-1,3,5-thiadiazine-2-thione derivatives were synthesized and tested in vitro against Trypanosoma cruzi and Trichomonas vaginalis. Some of them showed important antiprotozoan activity. In vivo assays of compounds which showed remarkable in vitro activity against T vaginalis were carried out.

Año de publicación:

1999

Keywords:

• Synthesis
• Trichomonas vaginalis
• TRYPANOSOMA CRUZI
• In vitro and in vivo studies
• 2H-1,3,5-Thiadiazine-2-thione derivatives
• Antiprotozoans

Fuente:

scopus

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