Synthesis and transformations of ne spiro-4-piperidines. Acetyl migration in 1-acetyl-1′-benzyl-4-methyl-3, 4-dihydrospiro [(1H)quinoline-2,4′-piperidines] under debenzylation conditions

Abstract:

Synthesis of new dihydrospiro[quinoline-2,4′-piperidines] by a two-step synthetic route based on 4-piperidone imine reactivity is reported. An acetyl migration in 1-acetyl-1′-benzyl-4-methyl-3,4-dihydrospiro [quinoline-2,4′-piperidines] under debenzylation conditions (HCOONH4/Pd/C/MeOH) is found. © 2005 Bentham Science Publishers Ltd.

Año de publicación:

2005

Keywords:

• Debenzylation
• Friedel-Craft alkylation
• Intramolecular alkene
• Acetyl migration
• Spiropiperidines

Fuente:

scopus