Synthesis of ¹³C,²H<inf>3</inf>-salmeterol: An analytical internal standard for pharmacokinetic studies

Abstract:

A convenient synthesis of an isotopically-labelled version (13C,2H3) of the longacting β2-adrenergic agonist, salmeterol, is described, starting from methyl salicylate, 1,6-dibromohexane and 4-phenyl-1-butanol. This compound was designed as an analytical internal standard for mass spectrometric determination of salmeterol in pharmacokinetic studies.

Año de publicación:

2000

Keywords:

• pharmacokinetics
• 13 2 C, H -salmeterol 3
• Mass spectrometry
• β -adrenergic agonist 2

Fuente:

scopus