Synthesis of dihydrodehydrodiconiferyl alcohol and derivatives through intramolecular C-H insertion


Abstract:

The natural dihydrobenzofuran neolignan 1 and its derivative 3 have been prepared through intramolecular C-H insertion catalyzed by a Rh(II) chiral complex. Moderate diastereo and enantioselectivities were observed. The cis and trans diastereomers were separated and unambiguously identified. The absolute configurations of the major isomers were established through chiral HPLC analysis and study of the Cotton effects in their circular dichroism curves. © 2006 Elsevier Ltd. All rights reserved.

Año de publicación:

2006

Keywords:

    Fuente:

    scopusscopus

    Tipo de documento:

    Article

    Estado:

    Acceso restringido

    Áreas de conocimiento:

    • Química orgánica
    • Bioquímica

    Áreas temáticas:

    • Química orgánica