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Synthesis of labelled PNA oligomers by a post-synthetic modification approach

Abstract:

The preparation of t-butoxycarbonyl (Boc)-protected O4-(o-nitrophenyl) thymine peptide nucleic acid (PNA) monomer is described. This PNA monomer was incorporated into PNA oligomer sequences. The post-synthetic modification of the oligomers to yield fluorescently-labelled PNA oligomers was studied before and after the removal of the protecting groups. In both cases, the desired fluorescently-labelled PNA oligomer was obtained in good yields. © 2002 Elsevier Science Ltd. All rights reserved.

Año de publicación:

2003

Keywords:

    Fuente:

    scopusscopus

    Tipo de documento:

    Article

    Estado:

    Acceso restringido

    Áreas de conocimiento:

    • Biotecnología
    • Biotecnología

    Áreas temáticas:

    • Farmacología y terapéutica
    • Química orgánica
    • Química física

    Contribuidores:

    B. G. De la TorreB. G. De la Torre
    Eritja R.Eritja R.