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T-Wave Morphology Changes as Surrogate for Blood Potassium Concentration in Hemodialysis Patients

Abstract:

End-stage renal disease (ESRD) patients undergoing hemodialysis (HD) are at high risk of arrhythmias and sudden cardiac death as a result of blood potassium concentration ([K+ ]) changes. The aim of this study is to investigate if d<inf>w</inf>, a time-warping-based electrocardiogram (ECG) biomarker of T-wave morphology changes, reflects [K+] evolution in HD patients, facilitating noninvasive [K+] monitoring and avoiding in-hospital blood tests analysis. 48-hour ECGs and a set of hourly-collected blood samples from 12 ESRD patients were acquired and analyzed. d<inf>w</inf> was calculated between a reference T-wave, measured at the end of the HD session, and the T-waves corresponding to each hour along the whole HD session, when [K+] was measured from blood samples. The values of d<inf>w</inf> correlated with the relative variations in [K+] with respect to the reference value (end of HD, Δ[K+ ]), with a median (interquartile) correlation coefficient of 0.90 (0.30), evidencing a strong relation between them. Our findings support the use of d<inf>w</inf> as a surrogate of Δ[K+], suggesting a potential use of d<inf>w</inf> for non-invasive hyperkalemia monitoring both in hospital and ambulatory settings.