TOMBU and COMBU as novel uronium-type peptide coupling reagents derived from oxyma-b

Abstract:

Here we describe two novel uronium salts, TOMBU and COMBU, derived from the recently described Oxyma-B for use in peptide bond synthesis. These coupling reagents are more stable than COMU in DMF. Furthermore, using various peptide synthetic models in solution and solid-phase synthesis, we reveal that they show better performance than HBTU in terms of preserving chiral integrity and coupling yields, but slightly worse performance than COMU.

Año de publicación:

2014

Keywords:

• Coupling reagents
• Peptide synthesis
• Oxyma-B
• amino acids
• Solid-phase peptide synthesis

Fuente:

scopus