The Cost-Effectiveness of Bendamustine-Rituximab Versus Fludarabine-Rituximab for Patients with Indolent Non-Hodgkin’s Lymphoma (INHL) Who Have Progressed Following Treatment …

Abstract:

Objectives To determine the cost-effectiveness of bendamustine-rituximab (Ben-R) versus fludarabine-rituximab (Fdb-R) in patients with iNHL who have progressed following treatment with rituximab or a rituximab-containing regimen in Colombia. Methods An economic model was constructed from the Colombian health system perspective, with a 35-year (lifetime) horizon and a discount rate of 3%. The model included three health states, progression-free (PF), progressive disease (PD), and death, which were associated with utility weights of 0.81, 0.62 and 0, respectively. Clinical inputs (response rates, Kaplan-Meier curves, hazard ratios (HRs) and adverse event rates) were from the Stil NHL 2-2003 study. Resource use data were from interviews with three Colombian hematologists treating iNHL patients. Unit costs were from ISS and SISPRO report and were expressed as 2013 Colombian Pesos. Univariate and …

Año de publicación:

2013

Keywords:

Fuente:

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