The Intensely Sweet Sesquiterpene Hernandulcin: Isolation, Synthesis, Characterization, and Preliminary Safety Evaluation

Abstract:

Details are provided of the isolation of an intensely sweet compound, hernandulcin, from Lippia dulcis Trev. (Verbenaceae), in addition to its synthesis, stereochemical assignation, spectroscopic and chromatographic characterization, derivatization, and thermal stability. This compound, as well as its analogue, epihernandulcin, and its products of thermal degradation, 3-methyl-2-cyclohexen-l-one and 6-methyl-5-hepten-2-one, exhibited LD50values in excess of 1 g/kg of body weight, when tested for acute toxicity in mice. All four compounds were also found to be nonmutagenic in forward mutation assays utilizing Salmonella typhimurium strain TM677. © 1987, American Chemical Society. All rights reserved.

Año de publicación:

1987

Keywords:

Fuente:

scopus