The Role of the Shape in the Design of New Nanoparticles

Abstract:

A number of design parameters that govern the functional behavior of nanocarriers, including the choice of polymer, particle size, and surface chemistry, have been in focus to optimize their performance in vivo. The size and shape of the nanoparticle strongly affects the transport through different biological barriers and circulation times. Currently, many novel shapes of nanoparticles exist, designed with different polymeric materials such as gold nanorods, carbon nanotubes, and fullerenes; and polymeric materials with hexagonal forms, helicoidal, toroidal, conical, ellipsoid, disks and others shapes synthesized with different monomer mixes. Another example is shapes made by fiber electrospun technique (sheet, attacked sheet, folded sheet, spiral wounded sheet, tube, and thread fibers). We discuss the methods of fabrication and the viability to synthesize new nanomaterials that can improve the release of drugs, the importance of particle shape and their role as a nanocarrier.

Año de publicación:

2014

Keywords:

• Particle shape
• Vectorization
• Non-polymer
• Drug release
• Particle
• Polymer particle
• nanocarrier
• Particle size

Fuente:

scopus