The backbone N-(4-azidobutyl) linker for the preparation of peptide chimera

Abstract:

A robust synthetic strategy for the introduction of the N-(4-azidobutyl) linker into peptides using standard SPPS techniques is described. Based on the example of Cilengitide it is shown that the N-(4-azidobutyl) group exerts similar conformational restraints as a backbone N-Me group and allows conjugation of a desired molecule either via click chemistry or - after azide reduction - via acylation or reductive alkylation. © 2013 American Chemical Society.

Año de publicación:

2013

Keywords:

Fuente:

scopus

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