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The effect of high frequency ventilation on cerebral blood flow and intracranial pressure in rabbits

Abstract:

The haemodynamic effects of conventional mechanical ventilation (CV) are well known. The unique haemodynamic effects of high frequency ventilation (HFV), such as decreased brain surface vessel movement, are less well understood. Several authors have studied cerebral blood flow (CBF) and intracranial pressure (ICP), but none have made these measurements across a broad range of blood pressures to determine if HFV alters cerebrovascular autoregulation and none have controlled for changes in intrathoracic volume that may occur when changing from CV to HFV. We hypothesized that HFV alters cerebrovascular autoregulation and cerebral blood flow compared to CV at the same blood pressure and intrathoracic volume.