The effects of tolazoline on intravascular pressures and cardiac output and its distribution during hypoxemia

Abstract:

In 7 awake, normoxic and subsequently hypoxemic unmedicated lambs, cardiac output (Q) was 956 ± 199 ml/min, heart rate (HR) 190 ± 48 beats/min and mean arterial pressure (MAP) 81 ± 9 torr during the normoxic control period. These changed to 1366 ± 573 ml/min, 237 ± 58 beats/min, 77 ± 14 torr and 41 ± 6 torr during hypoxemia. The addition of tolazoline to the hypoxemic, awake lamb did not reduce pulmonary artery pressure nor did it alter the cardiac output, heart rate or mean arterial pressure. Blood flow to gut, spleen, and kidney was reduced by hypoxemia and was reduced even more during tolazoline infusion. Brain blood flow increased 34% with hypoxemia and returned towards normal with increasing doses of tolazoline. Cardiac blood flow increased 300% from control during hypoxemia and did not decrease with tolazoline infusion. We also made 3 animals hypoxemic (PaO2 25 ± 4 torr) for 1.5 hours and found no deterioration of the preparation. It is concluded that the use of tolazoline in the treatment of neonatal pulmonary hypertension is not warranted.

Año de publicación:

1979

Keywords:

Fuente:

scopus