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The prognostic value of pretreatment platelet count in patients with head and neck squamous cell carcinoma

Abstract:

Objective Thrombocytosis is commonly observed in patients with solid tumors. This study aimed to evaluate the prognostic role of circulating pretreatment platelet count in a large series of patients with head and neck squamous cell carcinoma (HNSCC). Methods We retrospectively studied 824 patients with HNSCC treated at a single institution from 2000 to 2012. Disease-specific survival and local, regional, and distant recurrence-free survival were analyzed according to the distribution of the platelet count. Results By defining the platelet count 250.05 × 109/L as a cut-off point with the best predictive capacity, we classified the patients into two groups: those with a high platelet count (n = 378, 45.9%), and those with a low platelet count (n = 446, 54.1%). On univariate analysis, there were significant differences in disease-specific survival depending on pretreatment platelet count (P = 0.001). The 5-year specific survival …