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The role of purkinje automaticity as an arrhythmia mechanism in hyperkalaemia

Abstract:

The pacemaker activity of Purkinje (PK) cells is usually suppressed by the sino-atrial (SA) node. Under abnormal conditions, PK cells may produce ectopic focal activity leading to tachycardia and fibrillation. This computational modelling work illustrates the potential role of PK automaticity as an arrhythmia mechanism in hyperkalaemia. First, we investigated the automaticity of isolated PK cells under hyperkalaemic conditions. Second, the potential consequences of altered PK automaticity were explored in a 1-D model of a terminal PK fibre running through a hyperkalaemic zone. Hyperkalaemia was found to accelerate the autorhythmic period of isolated PK cells with respect to control. For extracellular potassium levels ≥ 7.2 mM, spontaneous action potentials (APs) appeared in the PK fibre, leading to conduction disturbances and complex combinations of spontaneous and stimulation-driven APs.