Total intravenous anesthesia with propofol in orthotopic liver transplantation in swine

Abstract:

Objective To study the use of total intravenous anesthesia with propofol as an anesthetic model for orthotopic liver transplantation (OLT) in pigs. ANIMALS AND METHOD: Fifteen OLT were performed in pigs using portacava-jugular veno-venous shunt with an injector pump. Anesthesia was maintained by perfusion of 10 mg/kg/h propofol. Hemodynamic and biochemical measurements were recorded at the following times: AO, baseline; AI, five minutes before removal of the liver; B1, five minutes later but before starting the bypass injector pump; B2, five minutes after starting the injector pump; B3, five minutes before reperfusion; C1, five minutes after starting reperfusion, and C2, after aortic declamping. Results No cases of malignant hyperthermia appeared. When the liver was removed cardiac output decreased (p< 0.01), as did mean arterial pressure (p< 0.01), mixed venous saturation (p< 0.05), pulmonary capillary pressure and temperature (p< 0.05). Pulmonary vascular resistances increased (p< 0.05). Conclusions The use of total intravenous anesthesia with propofol is a satisfactory experimental anesthetic model for OLT in pigs, and it prevents the possible appearance of malignant hyperthermia.

Año de publicación:

1997

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