Toxoplasma gondii infection blocks the development of allergic airway inflammation in BALB/c mice


Abstract:

There is a link between increased allergy and a reduction of some infections in western countries. Epidemiological data also show that respiratory allergy is less frequent in people exposed to orofaecal and foodborne microbes such as Toxoplasma gondii. Infection with T. gondii induces a strong cell-mediated immunity with a highly polarized T helper type 1 (Th1) response in early stages of infection. Using a well-known murine model of allergic lung inflammation, we sought to investigate whether T. gondii infection could modulate the susceptibility to develop respiratory allergies. Both acute and chronic infection with T. gondii before allergic sensitization resulted in a diminished allergic inflammation, as shown by a decrease in bronchoalveolar lavage (BAL) eosinophilia, mononuclear and eosinophil cell infiltration around airways and vessels and goblet cell hyperplasia. Low allergen-specific immunoglobulin (Ig …

Año de publicación:

2009

Keywords:

    Fuente:

    googlegoogle

    Tipo de documento:

    Other

    Estado:

    Acceso abierto

    Áreas de conocimiento:

    • Inmunología
    • Infección
    • Microbiología

    Áreas temáticas de Dewey:

    • Microorganismos, hongos y algas
    • Enfermedades
    Procesado con IAProcesado con IA

    Objetivos de Desarrollo Sostenible:

    • ODS 3: Salud y bienestar
    • ODS 15: Vida de ecosistemas terrestres
    • ODS 2: Hambre cero
    Procesado con IAProcesado con IA

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