Tramadol administered in a combination of routes for reducing pain after removal of an impacted mandibular third molar

Abstract:

Study Design This investigation was a double-blind, randomized, placebo-controlled clinical trial conducted in patients after extraction of an impacted mandibular third molar. Patients were assigned sequential numbers in the order of enrollment and received their allocated treatment according to a computer-generated randomization schedule prepared before the start of the study. Patients were randomized into 4 treatment groups, each with 12 patients: group A, tramadol 50 mg intramuscularly (IM) 1 hour before surgery; group B, tramadol 50 mg into the surgical site, injected submucosally immediately after local anesthesia; group C, tramadol through both routes of administration, 50 mg IM 1 hour before surgery and 50 mg into the surgical site; and group D, placebo (Fig 1). The tramadol dose through the local route was chosen with the aim of ensuring pain relief; that is, it was assumed that the drug was highly …

Año de publicación:

2007

Keywords:

Fuente:

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