Transcription and replication: Breaking the rules of the road causes genomic instability

Abstract:

Replication and transcription machineries progress at high speed on the same DNA template, which inevitably causes traffic accidents. Problems are not only caused by frontal collisions between polymerases, but also by cotranscriptional R-loops. These RNA-DNA hybrids induce genomic instability by blocking fork progression and could be implicated in the development of cancer. © 2010 Landes Bioscience.

Año de publicación:

2010

Keywords:

• R-loops
• Genomic instability
• Transcription-associated recombination
• DNA replication

Fuente:

scopus

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