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Treating obstetric antiphospholipid syndrome

Abstract:

Systemic autoimmune thrombosis or antiphospholipid syndrome is a treatable cause of miscarriages and of recurrent spontaneous pre-embryonic and embryonic abortions. Three groups of management could be identified for antiphospholipid syndrome. Low doses of aspirin and low-molecular-weight heparins are recommended for treatment of this disorder. The use of glucocorticoids and intravenous immunoglobulins can be justified in special cases. Strict control and an interdisciplinary approach during treatment of these patients is mandatory. Inflammatory autoimmune mechanisms in the pathophysiology of obstetric antiphospholipid syndrome and anti-inflammatory and immunomodulatory mechanisms of drug action should be considered during individual treatment scheme selection. © 2013 Future Medicine Ltd.