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Tuberculosis skin test and interferon gamma release assay concordance in infant Warao population, Delta Amacuro. Venezuela

Abstract:

Objective: To correlate the tuberculosis skin test (TST/PPD) and the interferon gamma release assay for the diagnosis of latent tuberculosis in infant Warao population, younger than fifteen years old is in the communities of Pedernales municipality, Delta Amacuro State, Venezuela, from September to November 2010. Methods: TST/PPD was applied in 473 individuals younger than fifteen years old; the positive reactors and the negative ones with confirmed TB patient contact were selected for assay with the Quanti-FERON® TB Gold In Tube test. Results: From 473 subjects with applied applied PPD, 97 of them resulted positive, 14 were negative having confirmed TB contact and 362 were negative. Quanti-FERON® TB Gold In Tube test was performed in 107 individuals (93 PPD positive plus 14 PPD negative with confirmed TB contact), 83 were positive, 21 were negative and 3 undetermined. The correlation between these two tests was calculated through kappa index, which was 0.9 and the statistical significance through Mac Nemar Chi2 test modified by Yates which was 3.25 (p>0.05). Conclusions: TST/PPD and interferon gamma release assay were concordant, almost perfectly, for the studied group. There was no statistical difference between TST/PPD and interferon gamma release assay. High latent tuberculosis prevalence was determined in these communities.