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Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern

Abstract:

The extent to which immune responses to natural infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and immunization with vaccines protect against variants of concern (VOC) is of increasing importance. Accordingly, here we analyse antibodies and T cells of a recently vaccinated, UK cohort, alongside those recovering from natural infection in early 2020. We show that neutralization of the VOC compared to a reference isolate of the original circulating lineage, B, is reduced: more profoundly against B.1.351 than for B.1.1.7, and in responses to infection or a single dose of vaccine than to a second dose of vaccine. Importantly, high magnitude T cell responses are generated after two vaccine doses, with the majority of the T cell response directed against epitopes that are conserved between the prototype isolate B and the VOC. Vaccination is required to generate high potency immune responses to protect against these and other emergent variants.

Año de publicación:

2021

Keywords:

    Fuente:

    scopusscopus

    Tipo de documento:

    Article

    Estado:

    Acceso abierto

    Áreas de conocimiento:

    • Inmunología
    • Inmunología

    Áreas temáticas:

    • Farmacología y terapéutica
    • Microorganismos, hongos y algas
    • Enfermedades

    Contribuidores:

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    Tipton T.Tipton T.
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    Goulder P.Goulder P.
    Cassar M.P.Cassar M.P.
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    Duncan C.J.A.Duncan C.J.A.
    Camara S.Camara S.
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    Rongkard P.Rongkard P.
    Dold C.Dold C.
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    de Silva T.I.de Silva T.I.
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    Harding A.C.Harding A.C.
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    O’Donnell D.O’Donnell D.
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