Unexpected and novel synthesis of spirojulolidines via intramolecular cyclization of N-carbethoxymethyl spirotetrahydroquinolines catalyzed by PPA

Abstract:

A series of N-carbethoxymethyl spirotetrahydroquinolines (6) were prepared and subjected to cyclization. We show that cyclization of (6) in the presence of excess PPA results in a 50-62% yield of unexpected spirojulolidines (7). © 2001 Elsevier Science Ltd. All rights reserved.

Año de publicación:

2001

Keywords:

• Spirolilolidine
• Spirojulolidine
• Intramolecular alkylation

Fuente:

scopus