Urban Residence Modifies The Association Between Atopy and Wheeze

Abstract:

Methods Two nested case-control studies were done among schoolchildren living in rural communities and urban neighbourhoods in the Province of Esmeraldas-Ecuador. Cases were defined as children with parentally-reported wheeze in the last year and controls as children with no history of wheeze. We measured geohelminths in stool samples and atopy by the specific IgE and skin prick test (SPT) reactivity to aeroallergens. Results Atopy, particularly measured as specific IgE against house dust mite (HDM), was more strongly associated with recent wheeze in urban than rural schoolchildren:(urban, adj. OR 5.19, 95% CI 3.37-8.00, P< 0.0001; rural, adj. OR 1.81, 95% CI 1.09-2.99, P= 0.02; interaction, P< 0.001). Twice as many wheeze cases were explained by atopy in urban compared to rural children: SPT to HDM (urban 18.5% vs. rural 9.6%), and anti-HDM IgE (urban 26.5% vs. rural 10.5%). The association …

Año de publicación:

2014

Keywords:

Fuente:

google