Value Of Clavulanic Acid In Basophil Activation Test For Evaluating Immediate Reactions To The Combination Amoxicillin-Clavulanic Acid

Abstract:

Methods Patients with a strong clinical history of having suffered an immediate reaction after AX-CLV administration were evaluated. The allergological study followed the European Academy guidelines, included skin test with penicillin G, AX, and CLV determinants and drug provocation test when indicated. BAT were carried out using AX and CLV at different concentrations (2.5, 1.25, 0.25 and 0.05 mg/ml). Results Among 75 patients included, 64 were finally diagnosed as allergic, 26 to AX and 38 to CLV. The sensitivity of BAT was 60% and the specificity 81.8%. The inclusion of AX determinant produced a BAT sensitivity of 54.1% whereas CLV determinant produced a BAT sensitivity of 78.6% with a specificity of 91% and 82% respectively. In patients diagnostic as allergic to AX the BAT sensitivity was 50% whereas in patients allergic to CLV, BAT sensitivity was 65.8%. Conclusions The inclusion of clavulanic acid in …

Año de publicación:

2014

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Fuente:

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