Volume-Targeted Versus Pressure-Limited Noninvasive Ventilation in Hypercapnic Respiratory Failure: What Could Be Established in Real Practice?

Abstract:

We have read with interest the original articletitled “Volume-TargetedVersusPressure-Limited Noninvasive Ventilation in Subjects with Acute Hypercapnic Respiratory Failure: A Multi-Center Randomized, Controlled Trial.” 1 In this study, Cao et al1 used a prospective, randomized controlled trial in the general respiratory wards to establish whether the ventilatory strategy with volume-targeted noninvasive ventilation (VT-NIV) was more effective than pressurelimited NIV (PL-NIV). We have some remarks on this study for practical implications. First, regarding methodology, we believe patient selection was inadequate, as only subjects with exacerbations of chronic pathologies (eg, COPD, asthma, bronchiectasis, and obstructive sleep apnea syndrome) were randomized into 2 groups of 29 subjects with similar demographics and blood gas analysis (pH-PCO2-PaO2/FIO2 and HCO3). The authors randomized subjects …

Año de publicación:

2017

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Fuente:

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