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W-M2ALIGN: A WEB-SERVER TOOL FOR PROTEIN MULTIPLE SEQUENCE ALIGNMENT BASED ON STRUCTURAL INFORMATION

Abstract:

This article presents w-M2Align, an easy and intuitive web-server tool for Protein Multiple Sequence Alignment based on the multiobjective metaheuristic M2Align, which aims to jointly optimize three accuracy metrics: STRIKE score, based on the structural information of the proteins, the Number of Totally Aligned Columns and the Percentage of Non-Gaps, based on the conservation of the structure of the sequences. The format of the biological sequences is compatible with the FASTA format and the structural information of the proteins can be provided by user or obtained automatically from the website of the Protein Data Bank (PDB) or. All computations are carried out in a dedicated computer cluster and users receive the results via URL or email. The platform allows downloading the files with the final results (Approximations to the Pareto Front and the set of alignments generated in FASTA format). The w-M2Align software is available at the web address http://revistas.uteq.edu. ec/m2align/, free of charge and does not require login for its use.