[O1–08–02]: ELEVATED CEREBROSPINAL FLUID NEUROFILAMENT LIGHT LEVELS ARE ASSOCIATED WITH COMPROMISED WHITE MATTER INTEGRITY AMONG OLDER ADULTS

Abstract:

Background White matter integrity, measured by diffusion tensor imaging (DTI), declines in normal aging and Alzheimer's disease (AD). Cerebrospinal fluid (CSF) neurofilament light (NFL) is a biomarker hypothesized to reflect large caliber, myelinated axonal injury. The association between CSF NFL and DTI metrics is poorly understood. The current research examined whether CSF NFL is associated with DTI measurements of white matter integrity in older adults free of clinical dementia and stroke. Methods Participants with normal cognition (NC, n= 77, 72±7), early mild cognitive impairment (MCI, n= 14, 73±6) and MCI (n= 56, 72±6) were drawn from the Vanderbilt Memory & Aging Project, a longitudinal observational study. Participants underwent a fasting lumbar puncture to obtain CSF NFL, Aβ 42, p-tau, and total tau (t-tau) concentrations (pg/mL) and multimodal 3T brain MRI. DTI data were analyzed using tract …

Año de publicación:

2017

Keywords:

Fuente:

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