[P2–386]: ABNORMAL CARDIAC STRUCTURE AND FUNCTION MEASURES ARE ASSOCIATED WITH INCREASED PERIVASCULAR SPACES IN OLDER ADULTS

Abstract:

Background Small vessel disease (SVD) is associated with incident cognitive decline and dementia, and neuroimaging markers of SVD have been associated with abnormal cardiovascular health. Research on perivascular spaces, an emerging marker of SVD, is sparse. Our study cross-sectionally investigated associations between cardiovascular health and perivascular spaces. Methods Vanderbilt Memory & Aging Project participants free of dementia, stroke, and heart failure (n= 328, 73±7 years) underwent echocardiography and cardiac MRI to measure left ventricular (LV) mass index, LV hypertrophy (LVH), cardiac index, LV ejection fraction (LVEF), and myocardial contraction fraction. A neuroradiologist used a combination of T1 and T2-weighted FLAIR images to manually code perivascular spaces in the basal ganglia and centrum semiovale. Regression models related cardiac measures, hypertension, and anti …

Año de publicación:

2017

Keywords:

Fuente:

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