[P3–314]: INTRACRANIAL ARTERY LUMEN DIAMETER RELATES TO CEREBRAL BLOOD FLOW AND CEREBROVASCULAR REACTIVITY IN MCI

Abstract:

Background Vessel wall imaging (VWI) is a novel neuroimaging technique that offers a critical first step toward understanding intracranial vessel morphology. Previous data suggest increased brain arterial diameter is a risk factor for vascular events and relates to both cerebral large and small vessel disease; however, the pathophysiology linking cerebrovascular remodeling to vascular disease requires further research. The current study examines the relationship between intracranial artery diameter to cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) among older adults. Methods Vanderbilt Memory & Aging Project participants free of clinical stroke and heart failure with normal cognition (NC, n= 74, 74±6 years) and mild cognitive impairment (MCI, n= 45, 74±8 years) were studied. Intracranial artery lumen diameter was measured across internal carotid artery (ICA), anterior cerebral artery (ACA), middle …

Año de publicación:

2017

Keywords:

Fuente:

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