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[P4–085]: SYNAPTONEMAL COMPLEX PROTEIN 2 LIKE GENE PROTECTS AGAINST HIPPOCAMPAL ATROPHY AND MEMORY DECLINE

Abstract:

Background Alzheimer's disease is characterized by progressive neurodegeneration and cognitive impairment, with early focal atrophy observed in the hippocampus. While hippocampal volume has been estimated to be 40–60% heritable, very little is known about the genetic drivers of hippocampal volume across the spectrum of normal aging and Alzheimer's disease. The current project sought to identify novel genetic drivers of hippocampal volume using a predicted gene expression model within the ADNI dataset. Methods Participants with normal cognition (n= 254, NC), mild cognitive impairment (n= 430, MCI) and Alzheimer's disease (n= 124, AD) were drawn from the Alzheimer's Disease Neuroimaging Initiative. Gene expression in the hippocampus was imputed using the PrediXcan method, which builds multi-single nucleotide polymorphism (SNP) predictors of gene expression from an expression quantitative …