Regresar

[P4–276]: APOE GENOTYPE INFLUENCES HOW CEREBRAL BLOOD FLOW AND VASOREACTIVITY PREDICT NEUROPSYCHOLOGICAL DECLINE OVER AN 18‐MONTH FOLLOW‐UP: THE VANDERBILT MEMORY AND AGING STUDY

Abstract:

Background Lower cerebral blood flow (CBF) and worse cerebrovascular reactivity (CVR) cross-sectionally relate to poorer neuropsychological performances among older adults, albeit inconsistently. Additional research is needed to elucidate how CBF and CVR may pbkp_redict cognitive trajectory longitudinally, particularly among individuals at risk for Alzheimer's disease (AD) and dementia. Methods Resting CBF and CVR were measured at baseline among 286 community-dwelling older adults free of clinical stroke or dementia (73±7 years) using pseudo-continuous arterial spin labeling magnetic resonance imaging. Quantified gray matter volume adjustments corrected for partial volume effects. Neuropsychological assessment was conducted at baseline and 18-month follow-up. Interactions of CBF and time point (baseline, 18-months) on cognitive outcomes related baseline CBF to longitudinal cognitive performance …

Año de publicación:

2017

Keywords:

    Fuente:

    googlegoogle

    Tipo de documento:

    Other

    Estado:

    Acceso abierto

    Áreas de conocimiento:

    • Neuropsicología
    • Neurología

    Áreas temáticas:

    • Enfermedades
    • Fisiología humana
    • Procesos mentales conscientes e inteligencia

    Contribuidores:

    Jefferson Michael Acosta OrtizJefferson Michael Acosta Ortiz