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[P4–276]: APOE GENOTYPE INFLUENCES HOW CEREBRAL BLOOD FLOW AND VASOREACTIVITY PREDICT NEUROPSYCHOLOGICAL DECLINE OVER AN 18‐MONTH FOLLOW‐UP: THE VANDERBILT MEMORY AND AGING STUDY

Abstract:

Background Lower cerebral blood flow (CBF) and worse cerebrovascular reactivity (CVR) cross-sectionally relate to poorer neuropsychological performances among older adults, albeit inconsistently. Additional research is needed to elucidate how CBF and CVR may predict cognitive trajectory longitudinally, particularly among individuals at risk for Alzheimer's disease (AD) and dementia. Methods Resting CBF and CVR were measured at baseline among 286 community-dwelling older adults free of clinical stroke or dementia (73±7 years) using pseudo-continuous arterial spin labeling magnetic resonance imaging. Quantified gray matter volume adjustments corrected for partial volume effects. Neuropsychological assessment was conducted at baseline and 18-month follow-up. Interactions of CBF and time point (baseline, 18-months) on cognitive outcomes related baseline CBF to longitudinal cognitive performance …