A facile route to substituted dimethoxy phosphonothionates using dimethyl thiophosphite

Abstract:

Dimethyl thiophosphite reacts with aliphatic aldehydes and ketones, Michael acceptors, and N-benzyl imines to afford excellent yields of α-hydroxy phosphonothionates, β-substituted phosphonothionates and α-amino phosphonothionates, respectively. Dealkylation of α-amino phosphonothionates affords N-benzyl α-amino phosphonothioic acids. Dimethyl thiophosphite reacts with electrophiles at a significantly greater rate than dimethyl phosphite.

Año de publicación:

2002

Keywords:

• α-amino phosphonothioic acids
• Dimethyl thiophosphite
• α-amino phosphonothionates
• α-hydroxy phosphonothionates
• β-substituted phosphonothionates

Fuente:

scopus