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Metabolite fingerprinting of Urospatha sagittifolia (Araceae) tubers at different growth stages by multi-platform metabolomics and molecular networking

Abstract:

Urospatha sagittifolia is a medicinal plant with antivenom, antihemorrhagic and anti-inflammatory properties commonly used by vulnerable Amazon indigenous communities to tackle venomous snakebites and their life-threatening consequences. Despite its pharmacological potential as a rich source of drug candidates, its metabolomic profile remains unknown. In this context, this study integrated mass spectrometry-based metabolomics, multivariate analysis, and molecular networks to uncover the chemical composition of U. sagittifolia and its dynamic metabolic changes during three plant growth stages (seedling, juvenile and adult). In general, 50 metabolites were identified in U. sagittifolia tubers by LC-MS (43 metabolites) and GC–MS (seven metabolites). Multivariate analysis using LC-MS showed that the relative concentrations of most of the identified metabolites were higher in seedlings or juveniles than in …