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Metabolism of tritiated vitamin D3 in familial vitamin D-resistant rickets with hypophosphatemia

Abstract:

The metabolism of tritiated vitamin D<inf>3</inf> in two control subjects and two with familial vitamin D-resistant rickets was studied. Sixteen hours after a 0.25 mg. intravenous dose of H<sup>3</sup> vitamin D<inf>3</inf> was given, blood samples were taken, extracted, and chromatographed. Both control and rachitic subjects produced in similar amounts a major, polar, biologically active metabolite previously discovered in rats. They also produced another minor chloroform soluble metabolite and aqueous soluble metabolites. Rachitic subjects retained about 60 per cent of the administered dose in blood after 16 hours, while controls retained only 20 per cent. The rachitic subjects had about 20 times more aqueous soluble metabolites in their blood than did the normal ones. © 1967 The C. V. Mosby Company.