Application of the technique CRISPR/Cas9 in the reduction and permanent inactivation of Huntington's Disease

Abstract:

A large amount of polyglutamine repeats gives rise to the neurodegenerative disease that is known as Huntington's disease. Among years, scientists have tried to find a mechanism that can stop the development of being sick but it still being discussed. Here, we review recent data from two experiments associated with the use of CRISPR/Cas9 whose objective is to find the most effective solution for the treatment of this disease. One of them consists of the reduction of expression of the mutant gene while the other seeks the permanent inactivation of this same gene.

Año de publicación:

2018

Keywords:

• Neurodegenerative
• Mutant gene
• Huntington Disease
• Huntingtin gene
• CRISPR/Cas9
• PAM

Fuente:

scopus