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Effects of transdermal: Nitroglicerin patches on inflammation and vascular lesion biomarkers in preeclamptic patients

Abstract:

Introduction and Objective: Pre-eclampsia is a multisystem disorder that complicates 3%-8% of pregnancies in Western countries and constitutes a major source of morbidity and mortality worldwide. The aim of this study was to examine the effects of transdermal nitroglycerin patches on biomarkers of inflammation and vascular lesion in pre-eclamptic patients. Materials and methods: a prospective study was done in 40 nulliparous preeclamptic patients over 25 weeks of gestation who attended the Obstetric Emergency at Hospital Central '‘Dr. Urquinaona’', Maracaibo, Venezuela. Interleukin 6 and 10, tumor necrosis factor alpha, interferon gamma, C-reactive protein, selectins (p, E and L) and asymmetric dimethylarginine concentrations were measured before and after nitroglycerin transdermal patches treatment (5 mg/twice a day) for 48 hours. Results: The mean maternal and gestational age was 21.77 ± 3.07 years and 34.23 ± 1.85 weeks respectively. A significant reduction was observed in systolic and diastolic blood pressure after treatment (p<0.05). However, no modifications were observed in Interleukin 6, Interleukin 10, tumor necrosis factor alpha, interferon gamma, C-reactive protein, selectins and asymmetric dimethylarginine concentrations. We concluded that treatment with nitroglycerin patches did not produce modifications in serum concentrations of inflammation and vascular lesion biomarkers in preeclamptic patients.