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Macrophage migration inhibitory factor in obese and non obese women with polycystic ovary syndrome

Abstract:

Objective: To measure macrophage migration inhibitory factor (MIF) concentrations in obese and non-obese women diagnosed with polycystic ovary syndrome (PCOS). Method: Women diagnosed with PCOS and age-matched healthy controls with regular mensese and normal ovaries on ultrasound examination were selected and divided into 4 groups (group A, PCOS and obese; group B, PCOS and non-obese; group C, obese controls; and group D, non-obese controls) based on body mass index (obese>30kg/m<sup>2</sup> y non-obese<25kg/m<sup>2</sup>). Luteinizing hormone, follicle-stimulating hormone, androstenedione, testosterone, sex hormone-binding globulin, serum glucose, insulin and MIF levels were measured. Results: Obese and non-obese women with PCOS had higher luteinizing hormone, follicle-stimulating hormone, androstenedione, testosterone, and insulin levels as compared to the obese and non-obese control groups, respectively (P<.0001). Women with PCOS had significantly higher MIF levels (group A, 48.6. ±. 9.9. mg/ml; group B, 35.2. ±. 6.0. ng/ml) as compared to controls (group C, 13.5. ±. 6.0. ng/ml; group D, 12.0. ±. 4.3. ng/dl; P<.0001). A weak, positive and significant correlation was seen between fasting blood glucose and insulin levels in women with PCOS (P<.05). Conclusion: Significant differences exist in plasma MIF levels between obese and non-obese women with and without PCOS.