Does the solid-phase synthesis of a tetrapeptide represent a challenge at the onset of the XXI century? The case of cyclo [(3R)-3-hydroxydecanoyl-L-seryl- (3R)-3-hydroxydecanoyl-L-seryl]

Abstract:

At the beginning of the XXI century, 43 years after the description of the first solid-phase synthesis of a tetrapeptide by Bruce Merrifield, the synthesis of a tetrapeptide may still represent a synthetic challenge. This is the case of serratamolide, a cyclic tetradepsipeptide originally found in a culture of Serratia marcescens, which exhibits interesting properties as a chemotherapeutic agent. Here we explore several methodologies for the synthesis of serratamolide in order to find a strategy that allows its preparation for further biological studies. © 2007 Springer Science+Business Media, LLC.

Año de publicación:

2007

Keywords:

• Cyclization
• Serratamolide
• solid-phase synthesis
• Tetradepsipeptide

Fuente:

scopus