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Association between nitric oxide and hypotension in patients at chronic hemodialysis in Maracaibo University Hospital

Abstract:

Hypotension is the most common clinical manifestation of hemodynamic instability during hemodialysis (HD) procedure. The origin of this hemodynamic disorder is multifactorial, but recently nitric oxide (NO) has been shown an important role on its pathophysiology since increased ON seric levels during HD have been demonstrated. Therefore the aim of this research was to determinate the association between seric levels of NO and hypotension during chronic HD in patients of the HD Unit of the University Hospital of Maracaibo. A non-experimental, descriptive and cross-sectional study was developed, which included 10 individuals with a history of hypotension in HD patients and 10 controls. Seric ON levels pre-dialysis were determinated, likewise during intradialysis hypotensive episode on the study group, and on the minute 107 of HD for the control group. The mean age of the study population was 49.15 ± 16.88 years. No differences were found between means of SBP, DBP and MBP pbkp_redialysis of the study groups, but intradialysis differences were found. Also significant differences were observed between ON intradialysis means of cases and controls (24,80±3,35 µM vs 31,89±4,06 µM respective, p=0,0445), but no differences were found in the pbkp_redialysis values (27,30±5,50 µM vs 29,70±9,44 µM, respective; p=0,496). It was concluded that individuals with hypotension have significantly higher ON levels during a hypotensive episode, compare with controls subjects.