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Association of Escherichia coli ST131 lineage with risk of urinary tract infection recurrence among young women

Abstract:

Objectives: The aim of this study was to test the hypothesis that urinary tract infections (UTIs) caused by Escherichia coli of the sequence type 131 (ST131) lineage are more likely to recur than UTIs caused by other E. coli lineages. Methods: Isolates from 221 young women with UTI caused by E. coli participating in a randomised controlled trial were used. Participants were followed for 6 months or until UTI recurrence. Results: Sequence type was not associated with risk of recurrence. Isolates in the ST131 lineage were more resistant than other STs to quinolones (6.2% vs. 1.3%) but not trimethoprim/sulfamethoxazole (15.4% vs. 15.0%). Conclusions: These results do not support an increased risk of recurrent UTI among otherwise healthy women with UTI caused by E. coli ST131.