Association of ppar gamma 2 GENE Pro12Ala allelic variant with obesity and metabolic syndrome components in a population of Maracaibo

Abstract:

Introduction: In this study the association of rs1801282 allelic variant, g. 68777C G (Pro12Ala) of PPAR gamma 2 gene with anthropometric and metabolic abnormalities was evaluated in a cohort of individuals with Metabolic Syndrome (MS) in Maracaibo Municipality. Methodology: The sample consisted of 127 individuals (81 with a diagnosis of MS, according to standardized criteria of expert panels IDF / AHA / NHLBI and 46 healthy subjects). Polymorphic versions of PPAR gamma 2 gene were analyzed by PCR-RFLP. Results: The frequency of the polymorphism of PPAR gamma 2 gene in the study population was 89 % for the Pro12Pro homozygous genotype and 11 % for Pro12Ala heterozygous genotype. The Ala12Ala homozygous variant genotype was not detected. The Pro12Ala heterozygous genotype was observed more frequently in patients in the MS group, although no significant genotypic (p=0.528) or …

Año de publicación:

2014

Keywords:

Fuente:

google