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A new antacid drug from activated carbon modified with calcium carbonate

Abstract:

Activated carbons were previously modified with different sodium carbonate solutions and then, they were soaked in a calcium nitrate solution. This procedure allowed to precipitate calcium carbonate on the microporous carbons. Then, these solids were washed with abundant distillated water. These modified carbons were characterized by means of XRD, SEM, HRTEM and BET surface area measurements. XRD confirmed the presence of calcium carbonate species, while the surface area measurements indicated that microporous solids were partially blocked. SEM and HRTEM showed that precipitated calcium carbonate crystals were found on the surface of the activated carbon. These solids were tested as antacids in a synthetic gastric juice and they were able to neutralize it. A commercial compound formulated with calcium carbonate was used as a reference system. © 2006 Elsevier B.V. All rights reserved.