Asymmetric synthesis of α-unsubstituted β-hydroxy acids

Abstract:

α-Unsubstituted β-hydroxy acid (3-hydroxycarboxylic acids) are constituents of various natural products with pharmacological and other technical properties of interest. They are also important intermediates in organic synthesis. This article reviews various possible routes for asymmetric synthesis of enantiopure or enantiomerically enriched α-unsubstituted β-hydroxy acids. © 2008 Bentham Science Publishers Ltd.

Año de publicación:

2008

Keywords:

• Reformatsky reactions
• 3-hydroxycarboxylic acids
• Arndt-Eister homologation
• β-lactones
• Reductive cleavage
• Cyclic sulfates
• Asymmetric aldol reactions
• Asymmetric reduction
• Cyclic sulfites

Fuente:

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