A new aspect of the antiproliferative action of peripheral-type benzodiazepine receptor ligands

Abstract:

Ro 5-4864 (4-chlorodiazepam), PK 11195 (1-(2-chlorophenyl)-1,3-dihydro-1-methyl-propyl)isoquinoline carboxamide) and diazepam inhibit, in a concentration-dependent way, the proliferation of V79 Chinese hamster lung cells (IC50 values were: 65.0 ± 3.73 μM, 57.70 ± 4.75 μM and 106.80 ± 8.89 μM, respectively) without being cytotoxic. This antiproliferative effect is mediated by mitosis arrest in the G2 + M stage without affecting DNA synthesis and seems unrelated to a specific interaction of these drugs with the peripheral-type benzodiazepine receptor. © 1995.

Año de publicación:

1995

Keywords:

• Lung
• (Chinese hamster)
• Benzodiazepine
• cell proliferation

Fuente:

scopus