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A new series of potent benzodiazepine γ-secretase inhibitors

Abstract:

A new series of benzodiazepine-containing γ-secretase inhibitors with potential use in the treatment of Alzheimer's disease is disclosed. Structure–activity relationships of the pendant hydrocinnamate side-chain which led to the preparation of highly potent inhibitors are described.

Año de publicación:

2003

Keywords:

    Fuente:

    googlegoogle

    Tipo de documento:

    Other

    Estado:

    Acceso abierto

    Áreas de conocimiento:

    • Farmacología
    • Farmacología

    Áreas temáticas:

    • Farmacología y terapéutica

    Contribuidores:

    Harrison CastroHarrison Castro