Autoantibodies and histocompatibility system in patients diagnosed with rheumatoid arthritis

Abstract:

Introduction: Rheumatoid arthritis is described as an autoimmune disease in which there is a genetic pattern with alterations in the histocompatibility system; HLA DR4 being the pattern that is most frequently reported in this disease. Objective: To identify the relationship between genetic alterations and seropositivity in patients diagnosed with rheumatoid arthritis. Methods: Observational, cross-sectional and descriptive research with a universe of 157 patients diagnosed with rheumatoid arthritis, of which 113 were part of the research sample. The presence of rheumatoid factor and anti-cyclic citrullinated peptide antibodies was determined, and a genetic study was performed to identify the presence of HLA-DR3 and HLA-DR4. The non-parametric Pearson correlation test was used to determine the correlation between the genetic pattern and seropositivity. Results: Average age of 58.74 years with a predominance of female patients (72.57 %); 38.05 % presented at least one associated comorbidity. Rheumatoid factor was positive in 60.18 % of the patients, while positive anti-cyclic citrullinated peptide was identified in 41.59 % of the cases studied. Genetic pattern alterations were identified in 66.37 % of the patients; HLA DR4 was present independently in 38.67 % of the positive cases and combined with HLA DR3 in 20.66 %. Conclusion: A significant positive correlation was identified between alterations in the genetic pattern and seropositivity. The presence of genetic pattern alterations triples the risk of seropositivity in patients with rheumatoid arthritis.

Año de publicación:

2022

Keywords:

• Rheumatoid Arthritis
• immunity
• Genetics
• Antibodies

Fuente:

scopus