B003: Erectil dysfunction in spanish treated essential hypertensives effects of sildenafil. preliminary report

Abstract:

To clarify the effects of long-term treatments with weight reduction (WR), ACE inhibitor (ACEI; enalapril) and angiotensin II antagonist (AIIA; candesartan) in obese hypertensives on BP reduction, especially focusing on sympathetic activity, renin angiotensin system (RAS), plasma insulin (INS) and leptin (LEP). Five groups with 20 obese hypertensives (HT) each were treated with WR alone, ACEI alone, AIIA alone, ACEI+WR, AIIA+WR over 12 months. WR was defined as 10% or more reduction in BMI for the first 6 months. The doses of ACEI and AIIA were chosen as less than 140/90 mmHg. At entry, month 6 & 12, BMI, BP, pulse rate (PR), plasma norepinephrine (NE), PRA, AII, INS and LEP were measured after overnight fast. WR program was performed in low caloric diet (1000 kcal, NaCl 7g/day) and exercise. At month 6, WR was succeeded in 65% of WR alone group, 60% of ACEI+WR, and 50% of AIIA+WR …

Año de publicación:

2000

Keywords:

Fuente:

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